The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.

Riley B, Kuo PH, Maher BS, Fanous AH, Sun J, Wormley B, O'Neill FA, Walsh D, Zhao Z, Kendler KS
Schizophr Res. 2009 115 (2-3): 245-53

PMID: 19800201 · PMCID: PMC2783814 · DOI:10.1016/j.schres.2009.09.008

BACKGROUND - DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples.

METHOD - We assessed nine single nucleotide polymorphisms (SNPs) in this gene for association with schizophrenia in a new sample of 1021 cases and 626 controls from Ireland.

RESULTS - Four SNPs give evidence of association (0.000018
CONCLUSION - This study provides further evidence from a large case/control sample for association of common DTNBP1 alleles and haplotypes with schizophrenia.

MeSH Terms (19)

Carrier Proteins Case-Control Studies Chi-Square Distribution Computational Biology Dysbindin Dystrophin-Associated Proteins Family Health Female Gene Frequency Genetic Predisposition to Disease Genotype Haplotypes Humans Ireland Logistic Models Male Polymorphism, Single Nucleotide Risk Factors Schizophrenia

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