Autologous stem cell transplant in a patient with Down syndrome and relapsed Hodgkin lymphoma.

Eckrich MJ, Domm J, Ho R, Whitlock JA, Frangoul H
Pediatr Blood Cancer. 2009 53 (7): 1327-8

PMID: 19760777 · DOI:10.1002/pbc.22182

Children with Down syndrome (DS) are at increased risk for the development of acute leukemia but they rarely develop other hematologic malignancies or solid tumors. Despite aggressive supportive care, DS patients have increased risk of treatment related morbidity and mortality compared to other children. There are few reported cases of Hodgkin disease in children with DS, and no reported cases of successful therapy for patients with relapsed disease. We report on a child with DS and relapsed Hodgkin disease who was successfully treated with high-dose chemotherapy and autologous stem cell transplant.

(c) 2009 Wiley-Liss, Inc.

MeSH Terms (25)

Antineoplastic Combined Chemotherapy Protocols Bleomycin Carmustine Child Combined Modality Therapy Cyclophosphamide Down Syndrome Doxorubicin Etoposide Granulocyte Colony-Stimulating Factor Hodgkin Disease Humans Ifosfamide Male Mesna Peripheral Blood Stem Cell Transplantation Prednisone Procarbazine Recurrence Remission Induction Transplantation, Autologous Transplantation Conditioning Vinblastine Vincristine Vinorelbine

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