Publication

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.

Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA, Pao W
J Clin Invest. 2009 119 (10): 3000-10

PMID: 19759520 · PMCID: PMC2752070 · DOI:10.1172/JCI38746

MeSH Terms (30)

Afatinib Amphiregulin Animals Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Antineoplastic Agents Cetuximab Disease Models, Animal Drug Resistance, Neoplasm EGF Family of Proteins Epidermal Growth Factor Epiregulin ErbB Receptors Erlotinib Hydrochloride Gene Expression Profiling Glycoproteins Humans Intercellular Signaling Peptides and Proteins Lung Neoplasms Male Mice Mice, Nude Mice, Transgenic Mutation Neoplasm Transplantation Paclitaxel Protein Kinase Inhibitors Quinazolines Transplantation, Heterologous Tumor Cells, Cultured

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