On the origin of event-related potentials indexing covert attentional selection during visual search.

Cohen JY, Heitz RP, Schall JD, Woodman GF
J Neurophysiol. 2009 102 (4): 2375-86

PMID: 19675287 · PMCID: PMC2775385 · DOI:10.1152/jn.00680.2009

Despite nearly a century of electrophysiological studies recording extracranially from humans and intracranially from monkeys, the neural generators of nearly all human event-related potentials (ERPs) have not been definitively localized. We recorded an attention-related ERP component, known as the N2pc, simultaneously with intracranial spikes and local field potentials (LFPs) in macaques to test the hypothesis that an attentional-control structure, the frontal eye field (FEF), contributed to the generation of the macaque homologue of the N2pc (m-N2pc). While macaques performed a difficult visual search task, the search target was selected earliest by spikes from single FEF neurons, later by FEF LFPs, and latest by the m-N2pc. This neurochronometric comparison provides an empirical bridge connecting macaque and human experiments and a step toward localizing the neural generator of this important attention-related ERP component.

MeSH Terms (15)

Action Potentials Animals Attention Electroencephalography Evoked Potentials Frontal Lobe Macaca radiata Male Neurons Neuropsychological Tests Reaction Time Task Performance and Analysis Time Factors Visual Cortex Visual Perception

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