PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.

Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB
Cell Metab. 2009 10 (2): 110-8

PMID: 19656489 · PMCID: PMC4012862 · DOI:10.1016/j.cmet.2009.07.002

MeSH Terms (22)

Animals Base Sequence DNA-Binding Proteins Doxycycline Glucose High Mobility Group Proteins Homeodomain Proteins Humans Insulin Insulin Secretion Islets of Langerhans Male Mice Mice, Transgenic Mitochondria Mitochondrial Proteins Promoter Regions, Genetic Rats Rats, Wistar Sodium-Calcium Exchanger Trans-Activators Transcription Factors

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