Publication

Axon growth-stimulus package includes local translation.

Macara IG, Iioka H, Mili S
Nat Cell Biol. 2009 11 (8): 919-21

PMID: 19648976 · PMCID: PMC2877918 · DOI:10.1038/ncb0809-919

Translation of localized mRNAs is an important mechanism for controlling spatially discrete cellular processes. The polarity protein Par-3 is locally translated in axons in response to factors such as NGF and netrin-1, and this increased expression is necessary for factor-stimulated axonal outgrowth.

MeSH Terms (16)

Animals Axons Carrier Proteins Cells, Cultured Gene Expression Models, Biological Nerve Growth Factor Nerve Growth Factors Netrin-1 Neurons Protein Binding Protein Biosynthesis Protein Kinase C Rats Signal Transduction Tumor Suppressor Proteins

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