Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.

Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC
Cancer Cell. 2009 16 (2): 115-25

PMID: 19647222 · PMCID: PMC2957372 · DOI:10.1016/j.ccr.2009.06.006

MeSH Terms (16)

Breast Neoplasms Cell Movement Cells, Cultured Cellular Senescence Female Humans Insulin Loss of Heterozygosity Ovarian Neoplasms Phosphatidylinositol 3-Kinases Phosphoric Monoester Hydrolases Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase Signal Transduction Substrate Specificity Tumor Suppressor Proteins

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