Williams R, Johnson KA, Gentry PR, Niswender CM, Weaver CD, Conn PJ, Lindsley CW, Hopkins CR
Bioorg Med Chem Lett. 2009 19 (17)
· PMCID: PMC2752865
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.
MeSH Terms (10)Allosteric Regulation Allosteric Site Anilides Animals Cyclohexanecarboxylic Acids Disease Models, Animal Parkinson Disease Rats Receptors, Metabotropic Glutamate Structure-Activity Relationship