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NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse.

McGuinness OP, Ayala JE, Laughlin MR, Wasserman DH
Am J Physiol Endocrinol Metab. 2009 297 (4): E849-55

PMID: 19638507 · PMCID: PMC2763792 · DOI:10.1152/ajpendo.90996.2008

This article addresses two topics. We provide an overview of the National Institutes of Health Mouse Metabolic Phenotyping Center (MMPC) Program. We then discuss some observations we have made during the first eight years of the Vanderbilt MMPC regarding common phenotyping practices. We include specific recommendations to improve phenotyping practices for tests of glucose tolerance and insulin action. We recommend that methods for experiments in vivo be described in manuscripts. We make specific recommendations for data presentation, interpretation, and experimental design for each test. To facilitate and maximize the exchange of scientific information, we suggest that guidelines be developed for methods used to assess glucose tolerance and insulin action in vivo.

MeSH Terms (12)

Animals Glucose Glucose Clamp Technique Glucose Intolerance Glucose Tolerance Test Homeostasis Hyperglycemia Insulin Resistance Mice National Institutes of Health (U.S.) Phenotype United States

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