Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine.

Barthel BL, Zhang Z, Rudnicki DL, Coldren CD, Polinkovsky M, Sun H, Koch GG, Chan DC, Koch TH
J Med Chem. 2009 52 (23): 7678-88

PMID: 19634903 · PMCID: PMC2788667 · DOI:10.1021/jm900694z

MeSH Terms (19)

Animals Antineoplastic Agents Blotting, Western Carbamates Carboxylesterase Cell Line, Tumor Cell Proliferation Doxorubicin Drug Evaluation, Preclinical Female Gene Expression Regulation, Enzymologic Humans Mice Myocytes, Cardiac Neoplasms Oxazoles Prodrugs Rats Regression Analysis

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