Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes.

Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP
J Biol Chem. 2009 284 (26): 17687-99

PMID: 19542237 · PMCID: PMC2719408 · DOI:10.1074/jbc.M109014274

MeSH Terms (15)

Archaeal Proteins Binding Sites Catalysis Crystallography, X-Ray DNA-Directed DNA Polymerase DNA Adducts Guanine Hydrogen Bonding Kinetics Nucleic Acid Conformation Protein Binding Protein Conformation Structure-Activity Relationship Substrate Specificity Sulfolobus solfataricus

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