Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct.

Irimia A, Eoff RL, Guengerich FP, Egli M
J Biol Chem. 2009 284 (33): 22467-22480

PMID: 19542228 · PMCID: PMC2755968 · DOI:10.1074/jbc.M109.003905

MeSH Terms (16)

8-Hydroxy-2'-Deoxyguanosine Base Sequence Catalysis Deoxyguanosine DNA-Directed DNA Polymerase DNA Replication Fungal Proteins Humans Kinetics Models, Biological Molecular Conformation Molecular Sequence Data Mutation Protein Structure, Tertiary Sulfolobus X-Ray Diffraction

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