Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines.

Sharma S, Kedrowski J, Rook JM, Smith RL, Jones CK, Rodriguez AL, Conn PJ, Lindsley CW
J Med Chem. 2009 52 (14): 4103-6

PMID: 19537763 · PMCID: PMC3192011 · DOI:10.1021/jm900654c

MeSH Terms (11)

Allosteric Regulation Animals Dose-Response Relationship, Drug Humans Inhibitory Concentration 50 Pyrimidines Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Stereoisomerism Structure-Activity Relationship

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