Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease.

Haase VH
Kidney Int. 2009 76 (5): 492-9

PMID: 19536078 · PMCID: PMC3623274 · DOI:10.1038/ki.2009.222

Epithelial-to-mesenchymal transition (EMT) is a developmentally vital, molecularly complex cellular process by which epithelial cells lose apico-basal polarity and cell-cell contact, become motile, and acquire mesenchymal characteristics. Under pathophysiological conditions EMT has a central role in cancer progression and metastasis, and has been associated with fibrotic disorders. Microenvironmental changes such as alterations in oxygen levels and activation of hypoxic signaling through hypoxia-inducible factor (HIF) are emerging as important triggers and modulators of EMT. Recent insights into potential molecular mechanisms underlying oxygen-dependent regulation of this process and their relevance to disease are discussed.

MeSH Terms (14)

Animals Cell Communication Cell Polarity Chronic Disease Epithelial Cells Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit Kidney Diseases Mesoderm Oxygen Repressor Proteins Signal Transduction Twist-Related Protein 1

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