Stereospecific formation of the (R)-gamma-hydroxytrimethylene interstrand N2-dG:N2-dG cross-link arising from the gamma-OH-1,N2-propano-2'-deoxyguanosine adduct in the 5'-CpG-3' DNA sequence.

Huang H, Kim HY, Kozekov ID, Cho YJ, Wang H, Kozekova A, Harris TM, Rizzo CJ, Stone MP
J Am Chem Soc. 2009 131 (24): 8416-24

PMID: 19530727 · PMCID: PMC2753404 · DOI:10.1021/ja809543j

MeSH Terms (13)

Base Pairing CpG Islands Cross-Linking Reagents Cyclopropanes Deoxyguanosine DNA DNA Adducts Hydrogen Bonding Models, Molecular Nuclear Magnetic Resonance, Biomolecular Nucleic Acid Conformation Stereoisomerism Thermodynamics

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