Pathology of graft-versus-host disease in the gastrointestinal tract.

Washington K, Jagasia M
Hum Pathol. 2009 40 (7): 909-17

PMID: 19524102 · DOI:10.1016/j.humpath.2009.04.001

Graft-versus-host disease (GVHD), a common complication of hematopoietic stem cell transplantation, is a clinical syndrome that requires synthesis of clinical, laboratory, and histopathologic findings for diagnosis. The gastrointestinal (GI) tract is commonly affected, and pathologists must recognize subtle morphologic alterations in GI mucosal biopsies to make the diagnosis and to rule out other causes of GI dysfunction such as cytomegalovirus infection and drug effects. This review summarizes the histopathologic features of GVHD in the GI tract and outlines recent recommendations for reporting of GI biopsies with suspected GVHD.

MeSH Terms (14)

Acute Disease Apoptosis Biopsy Child Chronic Disease Gastric Mucosa Gastrointestinal Diseases Gastrointestinal Tract Graft vs Host Disease Hematopoietic Stem Cell Transplantation Humans Intestinal Mucosa Organ Transplantation Transfusion Reaction

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