Neurotoxin quantum dot conjugates detect endogenous targets expressed in live cancer cells.

Orndorff RL, Rosenthal SJ
Nano Lett. 2009 9 (7): 2589-99

PMID: 19507837 · DOI:10.1021/nl900789e

High affinity peptide neurotoxins are effective agents for integrating technological advances with biological inquiries. Both chlorotoxin (CTX) and dendrotoxin-1 (DTX-1) are peptide neurotoxins demonstrated to bind targets expressed by glioma cancer cells and are suitable ligands for quantum dot (QD) live cell investigations. Here, we present dual labeling of endogenously expressed cellular proteins within living cells utilizing high affinity peptide neurotoxins conjugated to QDs. Multiplexing experiments reveal quantifiable evidence that CTX and DTX-1 conjugated QDs may potentially be used as a live assessment of markers toward identification of cancer cell presence.

MeSH Terms (10)

Animals Biomarkers, Tumor Biosensing Techniques Cell Line, Tumor Drug Delivery Systems Elapid Venoms Molecular Structure Neurotoxins Quantum Dots Scorpion Venoms

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