The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.

Veeriah S, Brennan C, Meng S, Singh B, Fagin JA, Solit DB, Paty PB, Rohle D, Vivanco I, Chmielecki J, Pao W, Ladanyi M, Gerald WL, Liau L, Cloughesy TC, Mischel PS, Sander C, Taylor B, Schultz N, Major J, Heguy A, Fang F, Mellinghoff IK, Chan TA
Proc Natl Acad Sci U S A. 2009 106 (23): 9435-40

PMID: 19478061 · PMCID: PMC2687998 · DOI:10.1073/pnas.0900571106

MeSH Terms (10)

DNA Methylation Gene Deletion Gene Expression Regulation, Neoplastic Glioblastoma Humans Mutation Neoplasms Phosphorylation Receptor-Like Protein Tyrosine Phosphatases, Class 2 STAT3 Transcription Factor

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