Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.

Tharp AC, Laha M, Panizzi P, Thompson MW, Fuentes-Prior P, Bock PE
J Biol Chem. 2009 284 (29): 19511-21

PMID: 19473980 · PMCID: PMC2740577 · DOI:10.1074/jbc.M109.005512

MeSH Terms (18)

Algorithms Animals Arginine Binding Sites Catalysis Cattle Drug Combinations Humans Kinetics Kringles Lysine Models, Molecular Mutation Plasminogen Protein Conformation Protein Structure, Tertiary Streptokinase Substrate Specificity

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