The calculus of integrating differentiation: timing control of T-bet.

Boothby M
Immunity. 2009 30 (5): 666-8

PMID: 19464989 · DOI:10.1016/j.immuni.2009.04.008

In this issue of Immunity, Schulz et al. (2009) use mathematical modeling to elucidate a signaling network controlling Ifng gene expression, thereby showing the importance of an Interleukin-12-dependent, Interferon-gamma-independent second phase of inducing the transcription factor T-bet.

MeSH Terms (10)

Animals Cell Differentiation Gene Expression Regulation Humans Interferon-gamma Interleukin-12 Models, Biological Signal Transduction T-Box Domain Proteins T-Lymphocytes, Helper-Inducer

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