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Risk of seizures after measles-mumps-rubella immunization.

Griffin MR, Ray WA, Mortimer EA, Fenichel GM, Schaffner W
Pediatrics. 1991 88 (5): 881-5

PMID: 1945626

To evaluate the risks of seizures and other neurologic events following measles-mumps-rubella (MMR) or measles-rubella (MR) immunization, a retrospective cohort study was conducted among 18,364 Tennessee children enrolled in Medicaid who received MMR or MR immunizations in their first 3 years of life. One hundred children had seizures at some time between immunization and 36 months; there were no encephalopathies during this period. Four children had febrile seizures in the 7 through 14 days following MMR or MR immunization compared with 72 in the interval 30 or more days following MMR or MR immunization yielding a relative risk (95% confidence interval) of 2.1 (0.7 to 6.4). Although not statistically significant, this increase in febrile seizures in the 7- through 14-day interval following MMR immunization is coincident with the occurrence of fever following MMR immunization and is consistent with reports of other investigators.

MeSH Terms (16)

Brain Diseases Child, Preschool Drug Combinations Follow-Up Studies Humans Infant Measles-Mumps-Rubella Vaccine Measles Vaccine Mumps Vaccine Regression Analysis Retrospective Studies Risk Factors Rubella Vaccine Seizures Tennessee Time Factors

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