Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.

Kulkarni SS, Zou MF, Cao J, Deschamps JR, Rodriguez AL, Conn PJ, Newman AH
J Med Chem. 2009 52 (11): 3563-75

PMID: 19445453 · PMCID: PMC2894482 · DOI:10.1021/jm900172f

MeSH Terms (11)

Alkynes Animals Cell Line Crystallography, X-Ray Humans Pyridines Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Structure-Activity Relationship Thiazoles

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