Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.

Bridges TM, Marlo JE, Niswender CM, Jones CK, Jadhav SB, Gentry PR, Plumley HC, Weaver CD, Conn PJ, Lindsley CW
J Med Chem. 2009 52 (11): 3445-8

PMID: 19438238 · PMCID: PMC3875304 · DOI:10.1021/jm900286j

MeSH Terms (8)

Allosteric Regulation Animals CHO Cells Cricetinae Cricetulus Isatin Mice Receptor, Muscarinic M5

Connections (5)

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