Evidence of effectiveness from a large county-wide school-based influenza immunization campaign.

Grijalva CG, Zhu Y, Griffin MR
Vaccine. 2009 27 (20): 2633-6

PMID: 19428871 · PMCID: PMC4825850 · DOI:10.1016/j.vaccine.2009.02.039

A school-based campaign in Knox County, TN immunized 41% and 48% of school children with live attenuated influenza vaccine in 2005 and 2006, respectively. We computed the relative risk (RR) of a positive rapid influenza test in Knox compared to Knox-surrounding county children (controls) during five baseline and two campaign seasons. Among children aged <5 years, the RR for a positive test remained relatively constant throughout the study seasons. Among children aged 5-17 years (target population), the RR was 1 during baseline and declined by 21% (RR, 0.79; 95% CI, 0.59-1.05) and 27% (RR, 0.73; 95% CI, 0.60-0.87) during the first and second campaign season, respectively. These findings suggest a direct beneficial effect of the immunization campaign.

MeSH Terms (14)

Adolescent Antigens, Viral Child Child, Preschool Humans Infant Influenza, Human Influenza Vaccines Orthomyxoviridae Schools Students Tennessee Vaccines, Attenuated Young Adult

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