A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.

Sheffler DJ, Williams R, Bridges TM, Xiang Z, Kane AS, Byun NE, Jadhav S, Mock MM, Zheng F, Lewis LM, Jones CK, Niswender CM, Weaver CD, Lindsley CW, Conn PJ
Mol Pharmacol. 2009 76 (2): 356-68

PMID: 19407080 · PMCID: PMC2713127 · DOI:10.1124/mol.109.056531

MeSH Terms (22)

Animals Binding, Competitive CHO Cells Cricetinae Cricetulus Dose-Response Relationship, Drug Electrophysiology Hippocampus Inhibitory Concentration 50 Learning Male Mice Molecular Structure Muscarinic Antagonists Patch-Clamp Techniques Rats Rats, Sprague-Dawley Receptor, Muscarinic M1 Seizures Sensitivity and Specificity Sulfonamides Thiadiazoles

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