The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems.

Loecken EM, Dasari S, Hill S, Tabb DL, Guengerich FP
Chem Res Toxicol. 2009 22 (6): 1069-76

PMID: 19364102 · PMCID: PMC2696559 · DOI:10.1021/tx900037u

MeSH Terms (10)

Alkyl and Aryl Transferases Cross-Linking Reagents DNA Epoxy Compounds Histones Humans Mutagenesis Mutagens Peptide Fragments Recombinant Proteins

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