Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

Konkle ME, Hargrove TY, Kleshchenko YY, von Kries JP, Ridenour W, Uddin MJ, Caprioli RM, Marnett LJ, Nes WD, Villalta F, Waterman MR, Lepesheva GI
J Med Chem. 2009 52 (9): 2846-53

PMID: 19354253 · PMCID: PMC2744100 · DOI:10.1021/jm801643b

MeSH Terms (13)

Amides Animals Antiparasitic Agents Cytochrome P-450 Enzyme Inhibitors Drug Evaluation, Preclinical Enzyme Inhibitors Extracellular Space Indomethacin Intracellular Space Ligands Sterol 14-Demethylase Sterols Trypanosoma cruzi

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