Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.

Vilar E, Mukherjee B, Kuick R, Raskin L, Misek DE, Taylor JM, Giordano TJ, Hanash SM, Fearon ER, Rennert G, Gruber SB
Clin Cancer Res. 2009 15 (8): 2829-39

PMID: 19351759 · PMCID: PMC3425357 · DOI:10.1158/1078-0432.CCR-08-2432

MeSH Terms (21)

Algorithms Antineoplastic Agents Benzoquinones Cell Cycle Cell Line, Tumor Chromones Colorectal Neoplasms Computational Biology DNA Mismatch Repair Drug Evaluation, Preclinical Enzyme Inhibitors Gene Expression Profiling Humans Hydroxamic Acids Immunosuppressive Agents Lactams, Macrocyclic Microsatellite Instability Morpholines Phosphoinositide-3 Kinase Inhibitors Proto-Oncogene Proteins c-akt Sirolimus

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