A dual DTI approach to analyzing white matter in children with dyslexia.

Carter JC, Lanham DC, Cutting LE, Clements-Stephens AM, Chen X, Hadzipasic M, Kim J, Denckla MB, Kaufmann WE
Psychiatry Res. 2009 172 (3): 215-9

PMID: 19346108 · PMCID: PMC2720547 · DOI:10.1016/j.pscychresns.2008.09.005

Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.

MeSH Terms (14)

Adolescent Anisotropy Brain Brain Mapping Case-Control Studies Child Diffusion Magnetic Resonance Imaging Dyslexia Female Functional Laterality Humans Image Processing, Computer-Assisted Male Neural Pathways

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