Characterization of the effects of methylmercury on Caenorhabditis elegans.

Helmcke KJ, Syversen T, Miller DM, Aschner M
Toxicol Appl Pharmacol. 2009 240 (2): 265-72

PMID: 19341752 · PMCID: PMC2753706 · DOI:10.1016/j.taap.2009.03.013

The rising prevalence of methylmercury (MeHg) in seafood and in the global environment provides an impetus for delineating the mechanism of the toxicity of MeHg. Deleterious effects of MeHg have been widely observed in humans and in other mammals, the most striking of which occur in the nervous system. Here we test the model organism, Caenorhabditis elegans (C. elegans), for MeHg toxicity. The simple, well-defined anatomy of the C. elegans nervous system and its ready visualization with green fluorescent protein (GFP) markers facilitated our study of the effects of methylmercuric chloride (MeHgCl) on neural development. Although MeHgCl was lethal to C. elegans, induced a developmental delay, and decreased pharyngeal pumping, other traits including lifespan, brood size, swimming rate, and nervous system morphology were not obviously perturbed in animals that survived MeHgCl exposure. Despite the limited effects of MeHgCl on C. elegans development and behavior, intracellular mercury (Hg) concentrations (

MeSH Terms (14)

Animals Caenorhabditis elegans Dose-Response Relationship, Drug Drug Resistance Environmental Pollutants Larva Longevity Methylmercury Compounds Nervous System Neurogenesis Neurons Pharyngeal Muscles Reproduction Time Factors

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