, a bio/informatics shared resource is still "open for business" - Visit the CDS website


Unified bundling and registration of brain white matter fibers.

Xu Q, Anderson AW, Gore JC, Ding Z
IEEE Trans Med Imaging. 2009 28 (9): 1399-411

PMID: 19336300 · PMCID: PMC3059198 · DOI:10.1109/TMI.2009.2016337

Magnetic resonance diffusion tensor imaging is being widely used to reconstruct brain white matter fiber tracts. To characterize structural properties of the tracts, reconstructed fibers are often grouped into bundles that correspond to coherent anatomic structures. For further group analysis of fiber bundles, it is desirable that corresponding bundles from different studies are coregistered. To address these needs simultaneously, a unified fiber bundling and registration (UFIBRE) framework is proposed in this work. The framework is based on maximizing a posteriori Bayesian probabilities using an expectation maximization algorithm. Given a set of segmented template bundles and a whole-brain target fiber set, the UFIBRE algorithm optimally bundles the target fibers and registers them with the template. The bundling component in the UFIBRE algorithm simplifies fiber-based registration into bundle-to-bundle registration, and the registration component in turn guides the bundling process to find bundles consistent with the template. Experiments with in vivo data demonstrate that the estimated bundles have an approximately 80% consistency with ground truth and the root mean square error between their bundle medial axes is less than one voxel. The proposed algorithm is highly efficient, offering potential routine use for group analysis of white matter fibers.

MeSH Terms (9)

Algorithms Bayes Theorem Brain Diffusion Magnetic Resonance Imaging Humans Image Processing, Computer-Assisted Models, Neurological Nerve Fibers Normal Distribution

Connections (1)

This publication is referenced by other Labnodes entities:

Links