A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.

Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M
Chem Commun (Camb). 2009 (15): 2017-9

PMID: 19333476 · PMCID: PMC2909737 · DOI:10.1039/b822781k

Crystal structures of A-form and B-form DNA duplexes containing 2'-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3'-endo pucker, illustrating that the replacement of electronegative oxygen at the 2'-carbon of RNA by sulfur does not appear to fundamentally alter the conformational preference of the sugar in the oligonucleotide context and sterics trump stereoelectronics.

MeSH Terms (6)

Crystallography, X-Ray DNA Nucleic Acid Conformation RNA Sulfhydryl Compounds Uridine

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