Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes.

Pentassuglia L, Graf M, Lane H, Kuramochi Y, Cote G, Timolati F, Sawyer DB, Zuppinger C, Suter TM
Exp Cell Res. 2009 315 (7): 1302-12

PMID: 19331811 · PMCID: PMC4991362 · DOI:10.1016/j.yexcr.2009.02.001

MeSH Terms (25)

Animals Antibiotics, Antineoplastic Calcium Cell Death Cells, Cultured Connectin Doxorubicin ErbB Receptors Extracellular Signal-Regulated MAP Kinases Female GATA4 Transcription Factor Male Mice Mitochondria Muscle Proteins Myocardial Contraction Myocytes, Cardiac Myofibrils Protein Kinase Inhibitors Proto-Oncogene Proteins c-akt Rats Rats, Wistar Receptor, ErbB-2 Receptor, ErbB-4 Signal Transduction

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