Publication

Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans.

Zhang MZ, Xu J, Yao B, Yin H, Cai Q, Shrubsole MJ, Chen X, Kon V, Zheng W, Pozzi A, Harris RC
J Clin Invest. 2009 119 (4): 876-85

PMID: 19307727 · PMCID: PMC2662561 · DOI:10.1172/JCI37398

MeSH Terms (22)

11-beta-Hydroxysteroid Dehydrogenase Type 2 Adenocarcinoma Adenoma Animals Base Sequence Cell Line, Tumor Colonic Neoplasms Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Enzyme Inhibitors Genes, APC Gene Silencing Glycyrrhizic Acid Humans Male Mice Mice, Inbred BALB C Mice, Mutant Strains Models, Biological Neovascularization, Pathologic Receptors, Glucocorticoid RNA, Small Interfering

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