Myeloma cells exhibit an increase in proteasome activity and an enhanced response to proteasome inhibition in the bone marrow microenvironment in vivo.

Edwards CM, Lwin ST, Fowler JA, Oyajobi BO, Zhuang J, Bates AL, Mundy GR
Am J Hematol. 2009 84 (5): 268-72

PMID: 19296472 · PMCID: PMC2753224 · DOI:10.1002/ajh.21374

MeSH Terms (17)

Animals Bone Marrow Bone Marrow Cells Boronic Acids Bortezomib Cell Communication Cell Line, Tumor Enzyme Activation Immunoglobulin G Mice Multiple Myeloma Neoplasm Transplantation Protease Inhibitors Proteasome Endopeptidase Complex Proteasome Inhibitors Pyrazines Tumor Burden

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