mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.

Ayala JE, Chen Y, Banko JL, Sheffler DJ, Williams R, Telk AN, Watson NL, Xiang Z, Zhang Y, Jones PJ, Lindsley CW, Olive MF, Conn PJ
Neuropsychopharmacology. 2009 34 (9): 2057-71

PMID: 19295507 · PMCID: PMC2884290 · DOI:10.1038/npp.2009.30

MeSH Terms (22)

Allosteric Regulation Animals Excitatory Amino Acid Agents Glutamic Acid Hippocampus In Vitro Techniques Learning Long-Term Potentiation Long-Term Synaptic Depression Male Maze Learning Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Neuronal Plasticity Phosphatidylinositols Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Receptors, N-Methyl-D-Aspartate Space Perception src-Family Kinases

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