Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential.

Schneider N, Krishna U, Romero-Gallo J, Israel DA, Piazuelo MB, Camargo MC, Sicinschi LA, Schneider BG, Correa P, Peek RM
J Infect Dis. 2009 199 (8): 1218-21

PMID: 19278338 · PMCID: PMC2828761 · DOI:10.1086/597416

Helicobacter pylori cagA-positive strains exert population-specific risks for gastric cancer. We determined whether variations in CagA phosphorylation motifs were associated with carcinogenic or proinflammatory epithelial phenotypes induced by strains from regions with divergent cancer risks (Colombia and Nashville, TN). Motif number was significantly related to levels of CagA phosphorylation and cytoskeletal abnormalities. Precancerous isolates possessed a higher number of motifs, and precancerous strains from Nashville induced higher levels of IL-8 than Colombian strains. These results indicate that CagA variants are linked with premalignant lesions in distinct populations and that epithelial responses to these strains are selective based upon locale.

MeSH Terms (18)

Amino Acid Motifs Antigens, Bacterial Bacterial Proteins Carcinoma Cell Line Colombia Female Helicobacter Infections Helicobacter pylori Host-Pathogen Interactions Humans Male Phenotype Phosphorylation Protein Isoforms Risk Factors Stomach Neoplasms Tennessee

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