p53 and MDM2: antagonists or partners in crime?

Eischen CM, Lozano G
Cancer Cell. 2009 15 (3): 161-2

PMID: 19249672 · DOI:10.1016/j.ccr.2009.02.004

Therapeutics that disrupt the p53-MDM2 interaction show promise for cancer treatment but surprisingly have different biological outcomes. A study by Enge et al. in this issue of Cancer Cell shows that the ability of MDM2 to target hnRNP K for degradation contributes to the decision to induce apoptosis rather than cell-cycle arrest.

MeSH Terms (9)

Animals Antineoplastic Agents Apoptosis Cell Cycle Gene Expression Regulation Humans Neoplasms Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53

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