Mdm2 affects genome stability independent of p53.

Bouska A, Eischen CM
Cancer Res. 2009 69 (5): 1697-701

PMID: 19244108 · DOI:10.1158/0008-5472.CAN-08-3732

Mdm2 is a critical negative regulator of the p53 tumor suppressor and is frequently overexpressed in human cancers. However, reports, including our own studies, suggest that Mdm2 has both p53-dependent and p53-independent functions that contribute to genomic instability and transformation when deregulated. We recently elucidated a p53-independent role for Mdm2 in the regulation of the DNA double-strand break repair response, genomic stability, and transformation through interaction with Nbs1, a member of the Mre11/Rad50/Nbs1 DNA double-strand break repair complex. In light of these findings, targeting Mdm2 in human malignancies may have effects other than activating p53.

MeSH Terms (11)

Animals Cell Cycle Proteins Cell Transformation, Neoplastic DNA Breaks, Double-Stranded DNA Repair Genomic Instability Humans Neoplasms Nuclear Proteins Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53

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