The utility of ketamine for the preoperative management of a patient with Parkinson's disease.

Wright JJ, Goodnight PD, McEvoy MD
Anesth Analg. 2009 108 (3): 980-2

PMID: 19224812 · DOI:10.1213/ane.0b013e3181924025

Loss of dopaminergic neurons from the substantia nigra characterizes the classical pathology of Parkinson's disease, but persistent activation of N-methyl-D-aspartate receptors is also a major component. During difficult airway management in a patient with advanced Parkinson's disease, the use of low-dose (20 mg) i.v. ketamine resulted in complete abolition of severe tremor and dysarthria. This led to the current case report in which low-dose ketamine was used for preoperative sedation and dyskinesia attenuation. Prior research and our experience would suggest that low-dose ketamine, titrated to effect, may provide optimal patient comfort and perioperative control of Parkinsonian tremor.

MeSH Terms (10)

Anesthesia, Inhalation Anesthetics, Dissociative Female Humans Intubation, Intratracheal Ketamine Middle Aged Parkinson Disease Perioperative Care Preanesthetic Medication

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