Comparison of methods to measure heart size using noncontrast-enhanced computed tomography: correlation with left ventricular mass.

Daniel KR, Bertoni AG, Ding J, Johnston S, Budoff MJ, Bluemke DA, Carr JJ
J Comput Assist Tomogr. 2008 32 (6): 934-41

PMID: 19204458 · DOI:10.1097/RCT.0b013e318159a49e

OBJECTIVE - Left ventricular (LV) mass is a useful independent predictor of cardiovascular events. We sought to develop a new correlate of LV mass using noncontrast-enhanced cardiac computed tomography (NCE-CCT).

METHODS - We assessed 22 different ventricular measurements made with NCE-CCT in 60 participants in the Multi-Ethnic Study of Atherosclerosis. The primary outcome was the correlation between the NCE-CCT measurements and magnetic resonance imaging (MRI)-derived LV mass.

RESULTS - Correlation coefficients (r) for the 22 NCE-CCT techniques in comparison to MRI-derived LV mass ranged from 0.12 to 0.80, with 14 of the 22 techniques having r > 0.7. The highest correlation was achieved using the modified Simpson Rule method to determine the biventricular volume (r = 0.80; P < 0.001). Interrater reliability was good, with intraclass correlation coefficients of 0.84 to 0.90 for the best (r > 0.75) NCE-CCT methods.

CONCLUSIONS - Noncontrast-enhanced cardiac computed tomography measurements of both biventricular volume and LV volume correlated well with MRI-derived LV mass in a population free of clinical cardiovascular disease.

MeSH Terms (21)

Aged Aged, 80 and over Cohort Studies Comorbidity Contrast Media Female Humans Imaging, Three-Dimensional Incidence Male Middle Aged Organ Size Radiographic Image Interpretation, Computer-Assisted Reproducibility of Results Risk Assessment Risk Factors Sensitivity and Specificity Statistics as Topic Tomography, X-Ray Computed United States Ventricular Dysfunction, Left

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