Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.

Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD
J Clin Invest. 2009 119 (3): 573-81

PMID: 19188683 · PMCID: PMC2648700 · DOI:10.1172/JCI37048

MeSH Terms (33)

Adenosine Diphosphate Adolescent Adult Animals Antioxidants Blood Glucose Body Mass Index Catalase Dietary Fats Electron Transport Glucose Clamp Technique Glucose Tolerance Test Glutathione Glutathione Disulfide Humans Hydrogen Peroxide Insulin Insulin Resistance Male Mice Mice, Inbred C57BL Mice, Transgenic Mitochondria Muscle Fibers, Skeletal Obesity Oligopeptides Oxidation-Reduction Oxidative Stress Oxygen Consumption Rats Rats, Sprague-Dawley Rodentia Young Adult

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