Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging.

Skala MC, Fontanella A, Hendargo H, Dewhirst MW, Izatt JA
Opt Lett. 2009 34 (3): 289-91

PMID: 19183634 · PMCID: PMC2715151 · DOI:10.1364/ol.34.000289

We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to noninvasively image changes in hemoglobin saturation, blood flow, microvessel morphology, and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over 24 h in dorsal skin fold window chamber tumors. There was a strong correlation between volumetric flow and hemoglobin saturation (rho=0.89, p=9x10(-6), N=15) and a moderate correlation between shear rate on the vessel wall and hemoglobin saturation (rho=0.56, p=0.03, N=15).

MeSH Terms (15)

Animals Blood Flow Velocity Cell Line, Tumor Computer-Aided Design Equipment Design Equipment Failure Analysis Hemoglobins Mice Neovascularization, Pathologic Reproducibility of Results Sensitivity and Specificity Skin Neoplasms Spectrum Analysis Systems Integration Tomography, Optical Coherence

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