Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2.

Harrison FE, May JM
Free Radic Biol Med. 2009 46 (6): 719-30

PMID: 19162177 · PMCID: PMC2649700 · DOI:10.1016/j.freeradbiomed.2008.12.018

Ascorbate (vitamin C) is a vital antioxidant molecule in the brain. However, it also has a number of other important functions, participating as a cofactor in several enzyme reactions, including catecholamine synthesis, collagen production, and regulation of HIF-1 alpha. Ascorbate is transported into the brain and neurons via the sodium-dependent vitamin C transporter 2 (SVCT2), which causes accumulation of ascorbate within cells against a concentration gradient. Dehydroascorbic acid, the oxidized form of ascorbate, is transported via glucose transporters of the GLUT family. Once in cells, it is rapidly reduced to ascorbate. The highest concentrations of ascorbate in the body are found in the brain and in neuroendocrine tissues such as adrenal, although the brain is the most difficult organ to deplete of ascorbate. Combined with regional asymmetry in ascorbate distribution within different brain areas, these facts suggest an important role for ascorbate in the brain. Ascorbate is proposed as a neuromodulator of glutamatergic, dopaminergic, cholinergic, and GABAergic transmission and related behaviors. Neurodegenerative diseases typically involve high levels of oxidative stress and thus ascorbate has been posited to have potential therapeutic roles against ischemic stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease.

MeSH Terms (14)

Animals Antioxidants Ascorbic Acid Biological Transport Brain Humans Ischemia Neurodegenerative Diseases Neurons Organic Anion Transporters, Sodium-Dependent Oxidative Stress Sodium-Coupled Vitamin C Transporters Symporters Synaptic Transmission

Connections (1)

This publication is referenced by other Labnodes entities: