Multi-pinhole collimator design for small-object imaging with SiliSPECT: a high-resolution SPECT.

Shokouhi S, Metzler SD, Wilson DW, Peterson TE
Phys Med Biol. 2009 54 (2): 207-25

PMID: 19088387 · PMCID: PMC2892935 · DOI:10.1088/0031-9155/54/2/003

We have designed a multi-pinhole collimator for a dual-headed, stationary SPECT system that incorporates high-resolution silicon double-sided strip detectors. The compact camera design of our system enables imaging at source-collimator distances between 20 and 30 mm. Our analytical calculations show that using knife-edge pinholes with small-opening angles or cylindrically shaped pinholes in a focused, multi-pinhole configuration in combination with this camera geometry can generate narrow sensitivity profiles across the field of view that can be useful for imaging small objects at high sensitivity and resolution. The current prototype system uses two collimators each containing 127 cylindrically shaped pinholes that are focused toward a target volume. Our goal is imaging objects such as a mouse brain, which could find potential applications in molecular imaging.

MeSH Terms (10)

Animals Biophysical Phenomena Brain Equipment Design Imaging, Three-Dimensional Mice Models, Theoretical Phantoms, Imaging Scattering, Radiation Tomography, Emission-Computed, Single-Photon

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