Stepping into the ring: the SIN takes on contractile ring assembly.

Roberts-Galbraith RH, Gould KL
Genes Dev. 2008 22 (22): 3082-8

PMID: 19056889 · DOI:10.1101/gad.1748908

The septation initiation network (SIN) regulates the timing of septum formation in Schizosaccharomyces pombe. However, whether and how the SIN functions in contractile ring formation has remained unclear. In this issue of Genes & Development, Hachet and Simanis (3205-3216) demonstrate that the SIN acts downstream from the Plo1 kinase to control a final step in contractile ring assembly. Furthermore, their careful analysis of contractile ring formation may help bridge two existing models of cytokinetic ring formation.

MeSH Terms (6)

Cell Cycle Contractile Proteins Cytokinesis Gene Expression Regulation, Fungal Schizosaccharomyces Schizosaccharomyces pombe Proteins

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