Phase I, pharmacokinetic and biological correlative study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor, and cisplatin in patients with solid tumors.

Ricart AD, Berlin JD, Papadopoulos KP, Syed S, Drolet DW, Quaratino-Baker C, Horan J, Chick J, Vermeulen W, Tolcher AW, Rowinsky EK, Rothenberg ML
Clin Cancer Res. 2008 14 (23): 7947-55

PMID: 19047127 · DOI:10.1158/1078-0432.CCR-08-0864

MeSH Terms (19)

Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols Cisplatin Female Genotype Glutarates Homocysteine Humans Isoindoles Male Maximum Tolerated Dose Middle Aged Neoplasms Polymerase Chain Reaction Polymorphism, Single Nucleotide Quinazolines Thymidylate Synthase

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