Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions.

Elias BC, Suzuki T, Seth A, Giorgianni F, Kale G, Shen L, Turner JR, Naren A, Desiderio DM, Rao R
J Biol Chem. 2009 284 (3): 1559-69

PMID: 19017651 · PMCID: PMC2615497 · DOI:10.1074/jbc.M804783200

MeSH Terms (23)

Animals Caco-2 Cells Chickens CSK Tyrosine-Protein Kinase Dogs Humans Hydrogen Peroxide Mass Spectrometry Membrane Proteins Mutation, Missense Occludin Oxidants Phosphoproteins Phosphorylation Protein-Tyrosine Kinases Protein Binding Protein Structure, Tertiary Proto-Oncogene Proteins Rats src-Family Kinases Tight Junctions Tyrosine Zonula Occludens-1 Protein

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