Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?

Yang L, Moses HL
Cancer Res. 2008 68 (22): 9107-11

PMID: 19010878 · PMCID: PMC2741321 · DOI:10.1158/0008-5472.CAN-08-2556

Therapies targeting transforming growth factor beta (TGFbeta) signaling using neutralizing antibodies and small molecular inhibitors are in multiple clinical trails. However, TGFbeta is known to work as both a tumor suppressor and a tumor promoter, and current knowledge does not provide sufficient information on what factors mediate this switch in function and when this switch occurs. Recent advances in multiple disciplines suggest that immune cells from the tumor host may provide the answer.

MeSH Terms (11)

Animals Carcinogens CD11b Antigen Humans Immune System Inflammation Myeloid Cells Receptors, Chemokine Signal Transduction Transforming Growth Factor beta Tumor Suppressor Proteins

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