Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease.

Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L
Proc Natl Acad Sci U S A. 2008 105 (46): 17931-6

PMID: 19004778 · PMCID: PMC2584730 · DOI:10.1073/pnas.0808242105

Intestinal intraepithelial lymphocytes (IEL) bear a partially activated phenotype that permits them to rapidly respond to antigenic insults. However, this phenotype also implies that IEL must be highly controlled to prevent misdirected immune reactions. It has been suggested that IEL are regulated through the interaction of the CD8alpha alpha homodimer with the thymus leukemia (TL) antigen expressed by intestinal epithelial cells. We have generated and characterized mice genetically-deficient in TL expression. Our findings show that TL expression has a critical role in maintaining IEL effector functions. Also, TL deficiency accelerated colitis in a genetic model of inflammatory bowel disease. These findings reveal an important regulatory role of TL in controlling IEL function and intestinal inflammation.

MeSH Terms (18)

Animals CD8-Positive T-Lymphocytes Cell Differentiation Cell Proliferation Colitis Colon Disease Models, Animal Epithelium Homeostasis Immunologic Memory Inflammatory Bowel Diseases Lymphocyte Count Lymphocytes Lymphocytic choriomeningitis virus Membrane Glycoproteins Mice Mice, Inbred C57BL Receptors, Antigen, T-Cell, alpha-beta

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